Blood testing to enhance case ascertainment during meningococcal meningitis outbreaks in the African meningitis belt (BloTIMA)

Principal Investigator: Brenda Kwambana Adams
Institution: University College London
Co-Investigators: Priscilla Ibekwe (Nigeria Centre for Disease Control/NCDC), Chikwe Ihekweazu (NCDC), Martin Antonio (World Health Organization Collaborating Centre for New Vaccines Surveillance/ WHOCC NVS), Robert Heyderman (UCL)

Start date: September 2019

This pilot study sets out to specifically determine the prevalence of meningococcal blood infections and determine the utility of blood testing to improve meningitis case ascertainment. The results of this study will form the case for support for large scale implementation studies to provide a more precise estimate of the scale of meningitis epidemics, to improve routine meningitis surveillance in sub-Saharan Africa and to investigate whether this approach enable more rapid confirmation of meningitis outbreak emergencies.

Aim and Impact

To evaluate the utility of a novel, low-cost, point of care diagnostic test leveraging lateral flow immunoassay for the detection of meningococcal bacteraemia