Dr Elizabeth Chan
Division of Infection and Immunity
University College London
Elizabeth is a postdoctoral research associate with the Heyderman group, studying factors that promote carriage, transmission and disease by Streptococcal species. Since carriage frequently precedes and accompanies streptococcal invasive disease, a better understanding of carriage and transmission would hopefully lead to new therapeutics. Elizabeth’s PhD work with the Dillard lab at University of Wisconsin-Madison focused on the interspecies variation in inflammatory peptidoglycan fragment release by the human restricted pathogens Neisseria gonorrhoeae and N. meningitidis and related non-pathogenic Neisseria. Her undergraduate research project in the Kearns lab at Indiana University Bloomington was on Bacillus subtilis flagellar stator proteins. Elizabeth’s long-term research goal is to identify and understand factors that allow typically non-pathogenic bacteria, such as S. pneumoniae and N. meningitidis, to transition to a pathogenic lifestyle.
Links to recent publications:
1) Chan JM, Dillard JP. 2017. Generation and release of pro-inflammatory peptidoglycan fragments by Neisseria. J Bacteriol 199:e00354-17. (Review)
2) Chan JM, Dillard JP. 2016. Neisseria gonorrhoeae crippled its peptidoglycan fragment permease to facilitate toxic peptidoglycan monomer release. J Bacteriol 198:3029-3040.
3) Woodhams KL, Chan JM, Lenz JD, Hackett KT, Dillard JP. 2013. Peptidoglycan fragment release from Neisseria meningitidis. Infect Immun 81:3490-3498.