Effect of long-term azithromycin on antimicrobial resistance in Streptococcus pneumoniae and Staphylococcus aureus colonizing HIV-infected children with chronic lung disease

Principal Investigator: Felix Dube
Institution: University of Cape Town, South Africa
Co-Investigators: Regina Abotsi, Mark Nicol, Shabir Madhi (RMPRU), Rashida Ferrand (LSHTM). John Odland (Norwegian University of Science and Technology)


Obliterative bronchiolitis (OB-CLD) is a form of chronic lung disease that affects more than 30% of perinatally HIV-infected children in sub-Saharan Africa. There are currently no standard guidelines for. treatment and management of OB-CLD; however, long term azithromycin (AZM) therapy has been proposed as a treatment option due to the drug's anti-microbial and anti-inflammatory properties. This study will investigate whether long-term AZM exposure drives the emergence of antimicrobial resistant strains of the mucosal pathogens Streptococcus pneumoniae and Staphylococcus aureus.