Effect of long-term azithromycin on antimicrobial resistance in Streptococcus pneumoniae and Staphylococcus aureus colonizing HIV-infected children with chronic lung disease

Principal Investigator: Felix Dube
Institution: University of Cape Town, South Africa
Co-Investigators: Regina Abotsi, Mark Nicol, Shabir Madhi (RMPRU), Rashida Ferrand (LSHTM). John Odland (Norwegian University of Science and Technology)

Start date: April 2020

Obliterative bronchiolitis (OB-CLD) is a form of chronic lung disease that affects more than 30% of perinatally HIV-infected children in sub-Saharan Africa. There are currently no standard guidelines for. treatment and management of OB-CLD; however, long term azithromycin (AZM) therapy has been proposed as a treatment option due to the drug's anti-microbial and anti-inflammatory properties. This study will investigate whether long-term AZM exposure drives the emergence of antimicrobial resistant strains of the mucosal pathogens Streptococcus pneumoniae and Staphylococcus aureus.

Aim and Impact

Understand the carriage prevalence and rates of antimicrobial resistance in S. pneumoniae colonizing children with and without long-term azithromycin exposure over time.