Maternal antenatal screening for Group B Streptococcus

People involved: Kirsty Le Doare, Philippa Musoke
Institution: Imperial College London, Makerere University

We propose to engage midwifery staff and pregnant women at Mulago hospital, to understand the acceptability and uptake of Group B Streptococcus (GBS) screening by rectovaginal swabs in pregnancy to prevent neonatal GBS disease; whether it is acceptable to take cord blood at delivery and infant blood if the infant becomes unwell. We will also seek to understand if a woman and her family would accept a minimally invasive autopsy if her infant is stillborn or if the infant dies from infection so that we can better understand the causes. We further wish to investigate understanding of maternal vaccination and potential barriers to offering it (midwifes) and uptake (pregnant women) in a high burden, low resource setting.  We aim to support the development of new and effective ways of involving the public who may be poorly literate in the context of implementing maternal vaccination to protect infants from disease.