Molecular characterization of Group B Streptococcus and its association with vaginal microbiome among pregnant women from low-middle income countries

Principal Investigator: Gaurav Kwatra, Shabir Madhi
Institution: University of The Witwatersrand, Johannesburg, South Africa
Co-Investigators: Takudzwa Matuvhunye

 

The relationship between colonisation by Group B Streptococcus and the vaginal microbiome in pregnant women is relatively understudied, especially in low- and middle-income countries (LMIC). The prevalence of concurrent colonisation by more than one serotype of GBS is also relatively unexplored. This study will determine the prevalence and density of multiple GBS serotype colonisation, as well as the vaginal micobiome of pregnant women from Bangladesh, South Africa, Ethiopia and Kenya. The survey data will then by used to characterize the vaginal microbiome associated with GBS colonisation in pregnant women in LMICs. The results from this study may better inform microbiome-related risk factors for GBS (multiple-serotype) colonisation, as well as anticipate any microbiome-related side effects that may arise due to depletion of GBS via vaccines.