Molecular evaluation of the association of the vaginal microbiome and adverse pregnancy outcomes in South Africa

Principal Investigator: Marta Nunes
Institution: Respiratory and Meningeal Pathogens Research Unit University of the Witwatersrand
Co-Investigators: Majoalane T.M. Ramatsebe, Courtney P. Olwagen, Vicky Baillie, Shabir A. Madhi

Start date: June 2019

This study seeks to determine if dysbiosis of the maternal vaginal microbiome (VBM) lead to adverse birth outcomes such as permaturity and low birthweight in a population of South African women delivering at Chris Hani Baragwanath Academic Hospital (CHBAH). Vaginal swabs for genotyping, as well as detailed demographic and clinical information will be collected at delivery to correlate the birth outcomes with the VMB composition and the clinical metadata.

Aim and Impact

To compare the composition of the vaginal microbiome between women who had a normal term deliver and those who had a stillbirth.