Analysis of commonalities across mucosal pathogens [Early Career Investigator Project]

Principal investigators: Kanny Diallo, Andrea Gori
Institution: Noguchi Memorial Institute for Medical Research and University College London

Start date: September 2018

In the past 20 years, several examples of similarities have been observed between structural components of Streptococcus agalactiae (GBS) and Streptococcus pneumoniae. Furthermore, GBS polysaccharide type III has been shown to induce an immune response that cross-react with vaccine serotype 14 of S. pneumoniae. In recent years, a wealth of newly sequenced pneumococci and GBS strains were deposited in public databases or are available within the MPRU. In this preliminary analysis, we propose to make use of these new genome data, together with custom datasets within BigSDB to discover and evaluate new potential similarities in the structural components of the S. agalactiae and S. pneumoniae species.

Aim and Impact

Identify new common structural components between the two pathogens, shedding light on the possibility of developing and implementing a pan-pathogen vaccine that confers protection against multiple mucosal pathogens.