Analysis of commonalities across mucosal pathogens [Early Career Investigator Project]

Principal investigators: Kanny Diallo, Noguchi Memorial Institute for Medical Research; Andrea Gori, University College London

In the past 20 years, several examples of similarities have been observed between structural components of Streptococcus agalactiae (GBS) and Streptococcus pneumoniae. Furthermore, GBS polysaccharide type III has been shown to induce an immune response that cross-react with vaccine serotype 14 of S. pneumoniae. In recent years, a wealth of newly sequenced pneumococci and GBS strains were deposited in public databases or are available within the MPRU. In this preliminary analysis, we propose to make use of these new genome data, together with custom datasets within BigSDB to discover and evaluate new potential similarities in the structural components of the S. agalactiae and S. pneumoniae species.