Assessing the potential of reduced dose immunisation strategies for pneumococcal conjugate use in Africa

Principal investigator: Stefan Flasche
Institution: London School of Hygiene and Tropical Medicine
Co-investigators: John Edmunds, Anthony Scott, John Ojal

Start date: September 2018

This project will use epidemiological data from three main sites of the MPRU: The Gambia, Kenya and Malawi. We will subsequently construct mathematical models to analyse factors under which a 1p+1 and a 2p+1 PCV13 immunisation schedule in Africa offer non-inferior protection to infants if compared to the current 3 dose infancy schedule.

Aim and Impact

Assess minimal campaign size needed to interrupt vaccine type pneumococcal transmission through a modelling study across three African sites.