Spatiotemporal dynamics of pneumococcal carriage in Blantyre, Malawi

Principal Investigator: Stefan Flasche
Institution: London School of Hygiene & Tropical Medicine
Co-Investigators: Billy Quilty, John Ojal, Neil French, Rob Heyderman, Stephane Hue, Todd Swarthout

Start date: December 2019

This study proposes to use analyses of spatial (temporal and geographical) patterns and bacterial phylogenetics to shed light on the dynamics of pneumococcal transmission. The study will leverage genomic and metadata obtained from cross-sectional samples collected in parts of Blantyre, Malawi from June 2015 and May 2019 to determine if fine scale clustering of S. pneumoanie occurs in either geographical space or time. The results of such analyses will improve understanding of the observed variability in pneumococcal epidemiology and help with design and interpretation of cluster randomised trials.

Aim and Impact

Identify spatial patterns of pneumococcal transmission across Blantyre from phylogenetic reconstruction, which will inform the design of cluster randomised trials and interventions to interrupt transmission chains.